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RECEPTOR, INTERFERON ALPHA-BETA
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DeCS
Descriptor
English
:
Receptor, Interferon alpha-beta
Descriptor
Spanish
:
Receptor de Interferón alfa y beta
Descriptor
Portuguese
:
Receptor de Interferon alfa e beta
Synonyms
English
:
Interferon alpha-beta Receptor
Tree Number:
D12.776.543.750.705.852.400.500
Definition
English
:
A ubiquitously expressed heterodimeric receptor that is specific for both
INTERFERON-ALPHA
and
INTERFERON-BETA
. It is composed of two subunits referred to as IFNAR1 and IFNAR2. The IFNAR2 subunit is believed to serve as the ligand-binding chain; however both chains are required for
signal transduction
. The
interferon alpha-beta receptor
signals through the action of
JANUS KINASES
such as the
TYK2 KINASE.
History Note
English
:
2007(1993)
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
52342
Unique Identifier:
D053633
Occurrence in VHL
:
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